反应详情

To a solution of phenol (2 g, 21.25 mmol) in CH3CN (50 mL) was added ethyl 2-bromo-2-methylpropanoate (5 g, 25.5 mmol) and Cs2CO3 (20 g, 63.75 mmol) at 25° C. The mixture was heated at reflux for 16 h then water (100 mL) added and extracted with ethyl acetate (2×50 mL). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound (2.1 g, 47.7%) as colorless oil which was used in next step without further purification.

1. temperatureThe mixture was heated
2. temperatureat reflux for 16 h
3. extractionextracted with ethyl acetate (2×50 mL)
4. washThe organic layer was washed with brine (30 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated