反应详情

To a solution of ethyl 2-methyl-2-phenoxypropanoate (2.0 g, 9.6 mmol) in EtOH (16 ml) was added a solution of NaOH (0.46 g, 11.5 mmol) in H2O (4 ml) at 26° C. The mixture was stirred for 30 min then concentrated. Water was added (20 mL) and washed with ethyl acetate (2×20 mL). The aqueous layer was acidified with 2N HCL until pH 3 and extracted with ethyl acetate (2×20 ml). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound (1.6 g, 94.1%) as a white solid which was used in next step without further purification.

1. concentrationthen concentrated
2. additionWater was added (20 mL)
3. washwashed with ethyl acetate (2×20 mL)
4. extractionextracted with ethyl acetate (2×20 ml)
5. washThe combined organic layers were washed with brine (30 mL)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated