HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1429481Generated: October 30, 2026
Potassium Carbonate → ethyl 2-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)acetate
https://huagongshe.com/reaction/1429481
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 5-Bromo-1-methyl-1H-pyrazole | HCID 17933381 | — |
| Reactant | Ethyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate | HCID 53217140 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Product | ethyl 2-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)acetate | HCID 90241563 | 70.4% |
Reaction Steps
A mixture of ethyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate (500 mg, 1.72 mmol), 5-bromo-1-methyl-1H-pyrazole (252 mg, 1.57 mmol), K2CO3 (651 mg, 4.71 mmol) and Pd(dppf)Cl2 (20 mg) in a solution of dioxane (10 mL) and H2O (2.5 mL) was stirred at 120° C. for 30 min under microwave. The catalyst was filtered through a pad of celite and the filtrate concentrated. The residue was purified by column chromatography to give the desired product (270 mg, Yield 70%) and used directly in the next step. LCMS (m/z): 245.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08940726B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-3cb252d8132443479f4cfffe8eb85d4d |
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| Source note | uspto-grants-2015_01 |
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