Ethyl bromoacetate → Ethyl 2-((2-methoxyquinolin-8-yl)oxy)acetate

Participants

Role	Name	HCID	Charge
Reactant	Ethyl bromoacetate	HCID 7748	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	8-Quinolinol, 2-methoxy-	HCID 762719	—
Solvent	Acetonitrile	HCID 6342	—
Product	Ethyl 2-((2-methoxyquinolin-8-yl)oxy)acetate	HCID 90237870	94%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a solution of 2-methoxyquinolin-8-ol (500 mg, 2.86 mmol) in MeCN (10 mL) was added ethyl 2-bromoacetate (501 mg, 3.0 mmol) and K2CO3 (789 mg, 5.72 mmol). The mixture was stirred at 80° C. for 5 h. The mixture was filtered and the filtrate evaporated to give the desired compound (700 mg, yield 94%). LCMS (m/z): 262.1 [M+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08940726B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-bd08b5ca9c5c48c5aab4c8172180954c
Source note	uspto-grants-2015_01