HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-propylpyrimidine → 6-Bromo-2-(4-(5-propylpyrimidin-2-yl)piperazin-1-yl)benzo[d]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-propylpyrimidine | HCID 2735784 | — |
| Reactant | 6-Bromo-2-piperazin-1-yl-1,3-benzothiazole | HCID 42281675 | — |
| Reactant | 6-Bromo-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole | HCID 67462793 | — |
| Product | 6-Bromo-2-(4-(5-propylpyrimidin-2-yl)piperazin-1-yl)benzo[d]thiazole | HCID 67466443 | — |
Reaction Steps
Compound 13C was prepared from Compound 13B and 2-chloro-5-propylpyrimidine in a similar manner to the procedure described for Compound 1C in Example 1. 1H NMR (500 MHz, chloroform-d) δ ppm 8.20 (2H, s), 7.73 (1H, dd, J=1.7, 0.6 Hz), 7.40-7.43 (2H, m), 3.96-4.00 (4H, m), 3.70-3.74 (4H, m), 2.44 (2H, t, J=7.4 Hz), 1.57-1.64 (2H, m), 0.95 (3H, t, J=7.3 Hz). LC/MS (m/z)=419 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940716B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-aec6cb20fcc64940a115419c4a76ceb3 |
| Source note | uspto-grants-2015_01 |