Cyclopropanesulfonyl chloride → 2-(1-(Cyclopropylsulfonyl)piperidin-4-yloxy)-6-(1-(propylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazole

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Reaction Steps

Example 22 was prepared from Compound 15A and cyclopropanesulfonyl chloride in a similar manner to the procedure described for Example 1. 1H NMR (599 MHz, DMSO-d6) δ ppm 7.93 (s, 1H), 7.62 (d, J=8.2 Hz, 1H), 7.50 (d, J=8.8 Hz, 1H), 6.23 (br. s., 1H), 5.35 (ddd, J=7.5, 3.7, 3.5 Hz, 1H), 3.96 (br. s., 2H), 3.50 (t, J=5.6 Hz, 4H), 3.35 (m, 2H), 3.00-3.14 (m, 2H), 2.60-2.69 (m, 3H), 2.15-2.26 (m, 2H), 1.98 (d, J=7.6 Hz, 2H), 1.70-1.82 (m, 2H), 0.94-1.10 (m, 7H). LC/MS (m/z)=526 (M+H)+.

Provenance & Evidence