2-Methoxyethyl chloroformate → 2-Methoxyethyl 4-(6-(1-(propylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazol-2-yloxy)piperidine-1-carboxylate

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Reaction Steps

Example 25 was prepared from Compound 15A and 2-methoxyethyl carbonochloridate in a similar manner to the procedure described in Example 15. 1H NMR (599 MHz, DMSO-d6) δ ppm 8.22 (s, 1H), 7.88 (s, 1H), 7.58 (d, J=8.2 Hz, 1H), 7.46 (d, J=8.8 Hz, 1H), 6.19 (br. s., 1H), 5.28-5.39 (m, 2H), 4.05-4.19 (m, 2H), 3.92 (br. s., 2H), 3.65-3.77 (m, 2H), 3.49-3.58 (m, 2H), 3.45 (t, J=5.6 Hz, 2H), 2.96-3.11 (m, 2H), 2.60 (br. s., 2H), 2.08 (d, J=8.8 Hz, 3H), 1.63-1.84 (m, 6H), 1.00 (t, J=7.3 Hz, 3H). LC/MS (m/z)=524 (M+H)+.

Provenance & Evidence