Trifluoroacetic acid → HCID 54596589, compound

Participants

Reaction Steps

To a solution of 2-methyl-4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butan-2-yl bis(2-(trimethylsilyl)ethyl) phosphate (85 mg, 0.098 mmol) in CH2Cl2 (511 μl) at 0° C. was added TFA (51.1 μl, 0.663 mmol). The mixture was stirred and gradually warmed to rt for 4 h. It was cooled to 0° C. and an aqueous solution of NaHCO3 (saturated, 0.5 mL) was added. The solvent was removed and the solid was collected via filtering. The solid was rinsed with cold H2O and ether. It was dried under vacuum to yield 2-methyl-4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butan-2-yl dihydrogen phosphate (53 mg, 0.079 mmol, 80% yield) as a white solid. 1H NMR (500 MHz, DMSO) δ 8.17 (s, 2H), 7.90 (s, 1H), 7.56 (d, J=8.5 Hz, 1H), 7.43 (d, J=8.6 Hz, 1H), 6.14 (s, 1H), 5.33 (s, 1H), 4.12 (d, J=13.6 Hz, 2H), 3.90 (s, 2H), 3.47 (dd, J=24.6, 14.8 Hz, 4H), 2.53 (s, 4H), 2.35-2.24 (m, 3H), 2.06 (m, 2H), 1.90 (m, 2H), 1.69 (m, 2H), 1.46 (dd, J=14.7, 7.4 Hz, 2H), 1.20 (s, 6H), 0.81 (t, J=7.3 Hz, 3H). LCMS (m/z)=665 (M+H)+.

Provenance & Evidence