HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-((1-(5-Propylpyrimidin-2-yl)piperidin-4-yl)methyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(1-(5-Propylpyrimidin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazole | HCID 67462795 | — |
| Reactant | tert-Butyl 4-(2-((1-(5-propylpyrimidin-2-yl)piperidin-4-yl)methyl)benzo[d]oxazol-6-yl)-5,6-dihydropyridine-1 (2H)-carboxylate | HCID 68208557 | — |
| Product | 2-((1-(5-Propylpyrimidin-2-yl)piperidin-4-yl)methyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]oxazole | HCID 68208486 | — |
Reaction Steps
Compound 29E was prepared from Compound 29D and TFA in a similar manner to the procedure described for Compound 1E in Example 1. LCMS (m/z)=418 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940716B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-2f7b7d2bdaef4a2db14acd4de315a324 |
| Source note | uspto-grants-2015_01 |