Diethyl Ether → HCID 54596658, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-(1-(5-bromopentylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)-2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazole (Example 30C, 22.8 mg, 0.035 mmol) in EtOH (1.5 mL) and Et3N (0.75 mL) was heated in microwave at 120° C. for 40 min. It was cooled to rt, Et2O (2 mL) was added. The solid was collected via filtering. The solid was dissolved in hot EtOH (0.5 mL), the vial was sealed and slowly cooled to rt. The precipitate was collected via filtering to afford the desired product as a white solid (15 mg, 51% yield). LCMS (m/z)=669 (M+H)+.

Provenance & Evidence