Lithium Hydroxide → HCID 68208467, compound

Participants

Reaction Steps

To a solution of 2-oxo-2-(2-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)ethylamino)ethyl acetate (32 mg, 0.05 mmol) in THF (1 mL) was added LiOH (saturated, aqueous, 0.5 mL). The mixture was stirred at rt overnight. It was extracted with DCM (3×2 mL). The combined organic layers were dried (Na2SO4), filtered, concentrated to afford the desired product as a white solid (28 mg, 95% purity, 89% yield). 1H NMR (400 MHz, CDCl3) δ 8.16 (s, 2H), 7.63 (m, 2H), 7.38 (m, 1H), 6.06 (m, 1H), 5.43 (m, 1H), 3.75 (m, 12H), 2.88-0.72 (m, 17H). LCMS (m/z)=601 (M+H)+.

Provenance & Evidence