Tetrabutylammonium Fluoride → Tert-butyl 4-(2-(piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperidine-1-carboxylate

Participants

Reaction Steps

To a solution of tert-butyl 4-(2-((1-((2-(trimethylsilyl)ethoxy)carbonyl)-piperidin-4-yl)oxy)benzo[d]thiazol-6-yl)piperidine-1-carboxylate (385 mg, 0.685 mmol) in THF (5 mL) was added a solution of TBAF (1 M in THF, 3.4 mL, 3.4 mmol). The mixture was stirred at rt for 4 h. The mixture was diluted with EtOAc (8 mL), washed with aq. NaOH (1 N, 5 mL), then brine. The organic layer was dried (Na2SO4), filtered, and concentrated to afford tert-butyl 4-(2-(piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperidine-1-carboxylate (337 mg, 0.807 mmol, 84% purity, 100% yield). The product was used without further purification. LCMS (m/z)=418 (M+H)+.

Provenance & Evidence