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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1429588Generated: November 1, 2026

Trifluoroacetic acid → 2-(1-(5-Methylpyrazin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazole

https://huagongshe.com/reaction/1429588

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant2-(1-(5-Propylpyrimidin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazoleHCID 67462795—
Reactanttert-Butyl 4-(2-(1-(5-methylpyrazin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1 (2H)-carboxylateHCID 68208488—
Product2-(1-(5-Methylpyrazin-2-yl)piperidin-4-yloxy)-6-(1,2,3,6-tetrahydropyridin-4-yl)benzo[d]thiazoleHCID 71269938—

Reaction Steps

Compound 50C was prepared from Compound 50B and TFA in a similar manner to the procedure described for Compound 1E in Example 1. LCMS (m/z)=408 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08940716B2
Source datasetuspto-grants-2015_01
ORD IDord-983e330f7c464254aa73779bf7f9ed23
Source noteuspto-grants-2015_01