HRID1429639

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66869549

未命名化合物

结构：CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(N)ccc3F)CO[C@H](C(F)(F)F)[C@H]2CS1

HCID68171522

未命名化合物

PRODUCTS

生成物

结构：CC(F)(F)c1cnc(C(=O)Nc2ccc(F)c([C@]34CO[C@H](C(F)(F)F)[C@H]3CSC(N)=N4)c2)cn1

HCID57523783

未命名化合物

PROCEDURE

实验过程

Synthesized from tert-butyl[(4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-5-trifluoromethyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl]carbamate and 5-(1,1-difluoroethyl)pyrazine-2-carboxylic acid according to the general procedure. 1H NMR (600 MHz, CDCl3) δ ppm 2.03 (t, J=18.8 Hz, 3 H), 2.82 (d, J=12.0 Hz, 1 H), 3.14 (d, J=12.4 Hz, 1 H), 3.35-3.46 (m, 1 H), 3.77-4.07 (m, 1 H), 4.20-4.93 (m, 4 H), 7.08 (dd, J=11.7, 9.0 Hz, 1 H), 7.56 (d, J=4.5 Hz, 1 H), 7.80-7.93 (m, 1 H), 8.87 (s, 1 H), 9.43 (s, 1 H), 9.59 (br. s., 1 H)