huagongshe.com
HRID1429643

反应详情

EQUATION

反应方程式

HRID 1429643 的结构方程式

REACTANTS

反应物

2
结构：Cc1cnc(C(=O)O)cn1
HCID122831

5-Methyl-2-pyrazinecarboxylic acid

C6H6N2O2

结构：CC(C)(C)OC(=O)NC1=N[C@@]2(c3cc(N)cc(F)c3F)CO[C@H](C(F)(F)F)[C@H]2CS1
HCID68171526

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnc(C(=O)Nc2cc(F)c(F)c([C@]34CO[C@H](C(F)(F)F)[C@H]3CSC(N)=N4)c2)cn1
HCID57523871

未命名化合物

PROCEDURE

实验过程

Synthesized from tert-butyl[(4aS,5S,7aS)-7a-(5-amino-2,3-difluorophenyl)-5-trifluoromethyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl]carbamate and 5-methylpyrazine-2-carboxylic acid according to the general procedure. 1H NMR (400 MHz, CDCl3+MeOD) δ ppm 2.68 (s, 3 H), 2.84 (dd, J=13.6, 3.8 Hz, 1 H), 3.15 (dd, J=13.9, 3.0 Hz, 1 H), 3.30-3.42 (m, 1 H), 3.88 (d, J=10.4 Hz, 1 H), 4.61 (d, J=8.6 Hz, 1 H), 4.68 (quin, J=7.2 Hz, 1 H), 7.13-7.25 (m, 1 H), 8.05 (ddd, J=11.6, 6.8, 2.8 Hz, 1H), 8.46 (s, 1 H), 9.30 (d, J=1.3 Hz, 1 H)