Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 6-(Trifluoromethyl)pyridazin-3-amine | HCID 59805859 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 935777-25-6 | HCID 59805860 | 33.1% |
Reaction Steps
A mixture of D6 (4.0 g, 24.5 mmol) and N-chlorosuccinimide (3.3 g, 24.5 mmol) in acetonitrile (160 ml) was heated at 70° C. for 18 h. After this period, the reaction was cooled to room temperature and the solvents evaporated in vacuo. The crude residue was purified by column chromatography (silica; 3%-5% methanol/dichloromethane) to give D7 (1.6 g, 33%). C5H3ClF3N3 requires 197; Found 198 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08940743B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-90b970214969402fb06786c7750dffe9 |
|---|
| Source note | uspto-grants-2015_01 |
|---|
