Isopropanol hydrochloride → HCID 59805858, compound

HRID 1429665Notes

Reaction equation

HRID 1429665 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[N:4][C:3]=1[NH:12][CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1.Cl.C(O)(C)C>CO>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[N:5]=[N:4][C:3]=1[NH:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 21912024Isopropanol hydrochlorideHCID 59805853HCID 59805853, compound

Product 1

HCID 59805858HCID 59805858, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of D8 (1.1 g, 2.9 mmol) and hydrochloric acid/isopropanol (6N, 20 ml) in methanol (100 ml) was stirred at room temperature for 18 h. After this period, the reaction mixture was evaporated in vacuo, the residue re-dissolved in methanol and the solution made alkaline with methanolic ammonia. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography (silica gel; 5%-15% methanolic ammonia in dichloromethane) to give D9 (70 mg, 9%). C10H12ClF3N4 requires 280; Found 281 (MH+).

Workup

  1. waitAfter this period
  2. customthe reaction mixture was evaporated in vacuo
  3. dissolutionthe residue re-dissolved in methanol
  4. concentrationThe reaction mixture was concentrated in vacuo
  5. customthe residue purified by column chromatography (silica gel; 5%-15% methanolic ammonia in dichloromethane)

Sources & evidence

ORD record
ord-175eea1820fc4be3859de1d5e722b02e
Source dataset
uspto-grants-2015_01
Patent number
US08940743B2

Reaction notes

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