HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1430111Generated: November 2, 2026
Cesium carbonate → N-[5-(2-tert-butyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]acetamide
https://huagongshe.com/reaction/1430111
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Acetamido-4-methylthiazole | HCID 280907 | — |
| Reactant | Tri-tert-butylphosphine tetrafluoroborate | HCID 2734635 | — |
| Reactant | 2-(tert-Butyl)-4-chloropyridine | HCID 58087981 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[5-(2-tert-butyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]acetamide | HCID 59293656 | — |
Reaction Steps
A mixture of 2-acetamido-4-methylthiazole (92 mg), 4-chloro-2-tert.butylpyridine (83 mg), palladium acetate (10.4 mg), tri-tert-butylphosphonium tetrafluoroborate (28.3 mg) and cesium carbonate (319 mg) in DMF under an argon atmosphere is heated for 3 hours at 150° C. The reaction mixture is cooled, filtered through celite, evaporated and purified by normal and then reversed phase chromatography to give the title compound
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08940771B2 |
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| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-6e32cceaf07d4400bef12ad6e3f9d47d |
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| Source note | uspto-grants-2015_01 |
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