Ammonia → HCID 57417080, compound

HRID 1430122Notes

Reaction equation

HRID 1430122 reaction equation
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([N:10]([CH3:12])[CH3:11])[CH2:7][NH:6]1)=O.[NH3:13]>CO>[CH3:11][N:10]([CH3:12])[C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([NH2:13])=[O:2])[CH2:9]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 51072228Methyl (4R)-4-(dimethylamino)-L-prolinate

Product 1

HCID 57417080HCID 57417080, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (2S,4R)-4-Dimethylamino-pyrrolidine-2-carboxylic acid methyl ester (225 mg) and 7M ammonia in methanol (7 ml) is stood for 18 hours at room temperature in a sealed vessel. Evaporation and trituration with diethyl ether gives the title compound as a white solid.

Workup

  1. customEvaporation and trituration with diethyl ether

Sources & evidence

ORD record
ord-495c0a1c47dc48d8af5a1916a15dcfce
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

Loading…