Ammonia → HCID 55285252, compound

HRID 1430132Notes

Reaction equation

HRID 1430132 reaction equation
C[O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([C:10]#[N:11])[CH2:7][NH:6]1)=O.[NH3:12]>CO>[C:10]([C@H:8]1[CH2:7][NH:6][C@H:5]([C:3]([NH2:12])=[O:2])[CH2:9]1)#[N:11]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14036245HCID 14036245, compound

Product 1

HCID 55285252HCID 55285252, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (2S,4R)-4-cyano-pyrrolidine-2-carboxylic acid methyl ester (22 mg) and 7M ammonia in methanol (0.24 ml) is stirred at room temperature for 1 hour. The reaction mixture is then evaporated to give the title compound which is used without further purification. MS (Method D) M+H 140.

Workup

  1. customThe reaction mixture is then evaporated

Sources & evidence

ORD record
ord-126cb7560168463f9d39e7dd1d5d9dab
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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