Ammonia → HCID 57417082, compound

HRID 1430141Notes

Reaction equation

HRID 1430141 reaction equation
C([O:5][C:6]([C@@H:8]1[CH2:12][C@H:11]([N:13]([CH3:15])[CH3:14])[CH2:10][NH:9]1)=O)CCC.[NH3:16]>CO>[CH3:14][N:13]([CH3:15])[C@@H:11]1[CH2:10][NH:9][C@H:8]([C:6]([NH2:16])=[O:5])[CH2:12]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58092718HCID 58092718, compound

Product 1

HCID 57417082HCID 57417082, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (2S,4S)-4-Dimethylamino-pyrrolidine-2-carboxylic acid butyl ester (326 mg) and 7M ammonia in methanol (8 ml) is stood for 18 hours at room temperature in a sealed vessel. Filtration, evaporation and trituration with diethyl ether/methanol gives the title compound as a beige solid.

Workup

  1. filtrationFiltration, evaporation and trituration with diethyl ether/methanol

Sources & evidence

ORD record
ord-4d2a1b9265794a1384d180f8cdac589b
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

Loading…