1-Butanol → HCID 58092718, compound

Participants

Reaction Conditions

Reaction Steps

Concentrated hydrochloric acid (0.3 ml) is added to a mixture of (2S,4S)-4-dimethylamino-pyrrolidine-2-carboxylic acid methyl ester dihydrochloride (400 mg) and 1-butanol (4 ml) and heated for 18 hours at 115° C. After cooling the reaction mixture is evaporated then partitioned between dicloromethane and aqueous sodium bicarbonate solution and the dichloromethane layers dried and evaporated to give the title compound as a brown oil which is used without further purification.

Provenance & Evidence