HRID1430157

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45117839

tert-Butyl (4-methyl-1,3-thiazol-2-yl)carbamate

C9H14N2O2S

HCID57417094

1-(4-Bromopyridin-2-yl)cyclobutane-1-carbonitrile

C10H9BrN2

PRODUCTS

生成物

结构：Cc1nc(NC(=O)OC(C)(C)C)sc1-c1ccnc(C2(C#N)CCC2)c1

HCID59293719

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

The title compound is prepared in analogy to the procedure described in Step 40.3, but using 1-(4-bromo-pyridin-2-yl)-cyclobutanecarbonitrile (Step 50.3) and (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (Step 17.4). The reaction mixture is stirred for 3 h at 100° C. Title compound: ESI-MS: 371.1 [M+H]+; tR=4.86 min (System 1); TLC: Rf=0.66 (Hex/EtOAc, 1:1).

WORKUP

后处理

customThe title compound is prepared in analogy to the procedure