Hydrochloric Acid → HCID 57506655, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (0.3 ml) is added to N-[5-(6-imidazol-1-yl-pyridin-2-yl)-4-methyl-thiazol-2-yl]-acetamide (30 mg) in ethanol (2 ml) and heated at reflux for 3 hours and then stood for 18 hours at room temperature. The reaction mixture is evaporated and partitioned between aqueous sodium bicarbonate solution and 10% methanol in dichloromethane, extracting a further 4× with 10% methanol in dichloromethane. Evaporation of the combined organic layers gives the title compound which is used in Step. 60.1 without further purification.

Provenance & Evidence