Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (Bromomethyl)cyclopentane | HCID 12723264 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 56978789 | HCID 56978789 | — |
Reaction Steps
A flask was charged with pyrazole (380 mg), (bromomethyl)cyclopentane (968 mg), tetrabutylammonium bromide (18 mg), 50% aqueous NaOH (0.6 mL) and toluene (1.5 mL) and the mixture was heated to 110° C. for 4.5 hours. The reaction mixture was cooled to room temperature and partitioned between toluene (3×10 mL) and H2O (10 mL). The extracts were dried (MgSO4), filtered, and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08940737B2 |
|---|
| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-0db9d783294744b8975ea872b964169d |
|---|
| Source note | uspto-grants-2015_01 |
|---|
