Methanol → HCID 86670057, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-carboxy-N,N-dimethyl-1-propanaminium chloride (2) (45.93 g, 0.27 mol) in anh. methanol (300 ml) at −10-0° C. slowly thionyl chloride (55 ml, 0.76 mol) was added and the temperature of the reaction mixture was allowed to rise to ambient temperature during ca. 1 h. The mixture was stirred at 40-50° C. for 3 h and evaporated. The residue was dissolved in acetone (110 ml) and precipitated by adding ether (400 ml). The solid was filtered, washed with ether, and once more dissolved in acetone (110 ml) followed by the precipitation with ether (400 ml). The precipitate was filtered, washed with ether, and dried to give 38.4 g (77%) of 4-methoxy-N,N-dimethyl-4-oxo-1-butanaminium chloride.

Provenance & Evidence