Dichloromethane → HCID 86715988, compound

Participants

Reaction Steps

A solution of methyl 4-(dimethylamino)butanoate (4) (3.39 g, 23.35 mmol) in anhydrous dichloromethane (50 ml) was stirred for 3 days at ambient temperature and 3 days under reflux. The reaction mixture was evaporated and the oily solid was triturated with diethyl ether (30 ml) in an ultrasound bath. The crystals were filtered, washed with diethyl ether and dried in vacuo over P2O5 to afford 2.36 g (44%) of N-(chloromethyl)-4-methoxy-N,N-dimethyl-4-oxobutan-1-aminium chloride.

Provenance & Evidence