HCID 86715988, compound → HCID 66575659, compound

Participants

Reaction Steps

A solution of N-(chloromethyl)-4-methoxy-N,N-dimethyl-4-oxobutan-1-aminium chloride (5) (2.39 g, 10.38 mmol) in water (10 ml) was passed through Amberlite® IRA-410 (OH) ion exchange resin column (100 ml) slowly (ca. 0.5 ml/min) eluting with water. To the eluate Dowex® 50WX8 ion exchange resin by small portions was added until the pH of the medium of the initial 9.5 was decreased up to 6.8-7.0 (pH control by a pH-meter). The reaction mixture was filtered, evaporated, and the residue was azeotropically dried successively with acetone, isopropanol, and acetonitrile followed by drying in vacuo over P2O5 to give 1.69 g (91%) of 4-[(chloromethyl)(dimethyl)ammonio]butanoate. M.p. 100.5-101° C.

Provenance & Evidence