Hydrochloric Acid → HCID 70673857, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-ethoxy-N-(2-fluoroethyl)-N,N-dimethyl-4-oxobutan-1-aminium chloride (4) from the preceding step (3.61 g, ≦514.2 mmol) in dioxane (10 ml) was added conc. HCl (5 ml) and the reaction mixture was stirred at 40° C. for 24 h. The mixture was evaporated, to the residue (3.02 g) was added conc.HCl (15 ml) and stirred at 70° C. for 2 h, then the mixture was evaporated again. The residue was triturated with acetonitrile in an ultrasound bath, then the mixture was decanted and the crystalline solid was washed with acetone. After drying in vacuo over P2O5 2.125 g of the 3-carboxy-N-(2-fluoroethyl)-N,N-dimethylpropan-1-aminium chloride (6) was obtained.

Provenance & Evidence