HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Fluoro-5-nitrobenzyl)morpholine → 4-Fluoro-3-(morpholinomethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Fluoro-5-nitrobenzyl)morpholine | HCID 86713637 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Fluoro-3-(morpholinomethyl)aniline | HCID 86713638 | 55.2% |
Reaction Steps
A mixture of 4-(2-fluoro-5-nitrobenzyl)morpholine (414 mg, 1.723 mmol) in EtOAc (15 mL) was treated with 10% Pd/C (100 mg) and hydrogenated (1 atm) for 3 h. The solids were removed via filtration, rinsed with EtOAc and the filtrate concentrated to dryness to afford 4-fluoro-3-(morpholinomethyl)aniline (200 mg, 55% yield). MS (ESI) m/z: 211.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940756B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-efe231f2f7eb4c66a610e7151cc77f1a |
| Source note | uspto-grants-2015_01 |