HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 1-(Bromomethyl)-3-fluoro-5-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-Fluoro-3-methyl-5-nitrobenzene | HCID 15065244 | — |
| Solvent | (Trifluoromethyl)benzene | HCID 7368 | — |
| Product | 1-(Bromomethyl)-3-fluoro-5-nitrobenzene | HCID 64770545 | 63% |
Reaction Conditions
| Temperature | 105 °C |
|---|
Reaction Steps
A solution of 3-fluoro-5-nitrotoluene (1.0 g, 6.45 mmol) in trifluorotoluene (15 ml) was treated with NBS (1.721 g, 9.67 mmol) and AIBN (0.212 g, 1.289 mmol) and heated at 105° C. overnight. The mixture was cooled to RT, the solids removed via filtration and the filtrate concentrated to dryness to afford 1-(bromomethyl)-3-fluoro-5-nitrobenzene (95 mg, 63% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940756B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7571780bdebc4b4ab84ba4cdc975f06e |
| Source note | uspto-grants-2015_01 |