HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropenyl chloroformate → HCID 131730625, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropenyl chloroformate | HCID 93846 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(5-Amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1h)-one | HCID 87771576 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131730625 | HCID 131730625 | 94.3% |
Reaction Steps
A bi-phasic mixture of Example A3 (250 mg, 0.710 mmol) in EtOAc (10 mL) and satd. NaHCO3 (15 mL) was treated with isopropenyl chloroformate 9120 mg, 0.984 mmol) and stirred at RT for 2 h. The layers were separated, the organic layer washed with water, then brine, dried over Na2SO4 and concentrated to dryness to afford prop-1-en-2-yl (4-chloro-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate (292 mg, 94% yield). MS (ESI) m/z: 436.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940756B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-838e22adb03043199c36b0c61565533b |
| Source note | uspto-grants-2015_01 |