Aluminum(III) Chloride → HCID 21453475, compound

Participants

Reaction Steps

To a solution of 2-benzyl-6-chloro-5-phenylpyridazin-3(2H)-one (1.45 g, 4.89 mmol) in toluene (15 mL) under argon at 90° C. was added aluminum chloride (1.629 g, 12.22 mmol) and the reaction was stirred for 20 min. It was then allowed to cool to room temperature and quenched with water, extracted with EtOAc, dried over MgSO4 and concentrated. The residue was purified by preparative HPLC to give the title compound as a white solid (847.6 mg). LCMS m/z=207 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 6.97 (s, 1H), 7.41-7.54 (m, 5H).

Provenance & Evidence