Hydrochloric Acid → Cyclohexanecarboxylic acid, 1-(p-chlorophenoxy)-

Participants

Reaction Steps

To a suspension of NaOH (2.8 g, 70.02 mmol) in THF (10 ml) added 4-chloro phenol (1 g, 7.78 mmol) and stirred for 15 min at r.t. Reaction mixture was cooled to 0° C. Cyclohexanone (7.62 g, 77.8 mmol) was added, followed by drop wise addition of anhydrous CHCl3 (2.5 ml, 31.12 mmol) over a period of 15-20 min. The reaction mixture was stirred for 14-18 hr allowing the temperature to rise to room temperature. Reaction mixture was neutralized with (HCl, pH˜7) and was extracted with EtOAc (3×50 mL). The organic phase were successively washed with 2% HCl (50 mL), brine (50 mL) and dried over Na2SO4. After evaporation of solvent, the residue was used as such for the next step.

Provenance & Evidence