1,2-Dichloroethane → HCID 67486005, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-Amino-phenoxy)-2-methyl-propionic acid ethyl ester (0.2 g, 0.89 mmol) in 1,2-dichloroethane (3 ml) acetone (6.6 ml, 89.6 mmol) and acetic acid (0.053 g, 0.89 mmol) were added. The reaction mixture was cooled to 0° C. Sodium triacetoxyborohydride (0.266 g, 1.25 mmol) was added and stirred at r.t. for 24 h. The reaction mixture was quenched with saturated NaHCO3 and extracted in DCM (20 ml), washed with brine, dried over Na2SO4 and concentrated under reduced pressure to obtain crude product. Purification on silica gel (MeOH:CHCl3) yielded 0.14 g (60%) of 2-(3-Isopropylamino-phenoxy)-2-methyl-propionic acid ethyl ester which was hydrolyzed using a typical procedure A1 and used as such for the next step.

Provenance & Evidence