Toluene → HCID 59363834, compound

Participants

Reaction Steps

2-(3-Amino-phenoxy)-2-methyl-propionic acid ethyl ester (0.52 g, 2.36 mmol) was dissolved in Toluene (2 ml) and acetylacetone (0.53 m, 4.4 mmol) was added to the solution. The resulting mixture was refluxed for 6 h with a Dean-Stack apparatus. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The crude material thus obtained was purified by flash column affording 2-[3-(2,5-Dimethyl-pyrrol-1-yl)-phenoxy]-2-methyl-propionic acid ethyl ester (0.5 g, 71%). 1H NMR (400 MHz, CDCl3): 1.): 1.24 (t, J=7.2 Hz, 3H), 1.57 (s, 6H), 2.02 (s, 6H), 4.23 (q, J=7.2 Hz, 2H), 5.88 (s, 2H), 6.71 (s, 1H), 6.83-6.91 (m, 2H), 7.26-7.33 (m, 1H); MS (EI) m/z: 302 (M+1).

Provenance & Evidence