Trifluoroacetic acid → HCID 24959769, compound

Participants

Reaction Steps

To a solution of 3-[1-Methyl-1-(thiazol-2-ylcarbamoyl)-ethoxy]-benzoic acid tert-butyl ester (0.1 g, 0.275 mmol) in DCM (2 ml) a solution of TFA (3 ml) in DCM (3 ml) was added at 0° C. for 15 min. Reaction mixture was stirred at RT for 1 h, diluted with DCM (10 ml) washed with brine (2×4 ml) dried over Na2SO4 and concentrated under reduced pressure to obtain crude product. The crude product was triturated with hexane to obtain white solid, filtered and dried to obtain 3-[1-Methyl-1-(thiazol-2-ylcarbamoyl)-ethoxy]-benzoic acid (0.06 g, 85%). 3-[1-Methyl-1-(thiazol-2-ylcarbamoyl)-ethoxy]-benzoic acid.

Provenance & Evidence