Acetyl chloride → HCID 24960137, compound

HRID 1430629Notes

Reaction equation

[NH2:1][C:2]1[C:3]([NH:8][C:9](=[O:21])[C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[N:15]=2)([CH3:12])[CH3:11])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:22](Cl)(=[O:24])[CH3:23]>>[C:22]([NH:1][C:2]1[C:3]([NH:8][C:9](=[O:21])[C:10]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[N:15]=2)([CH3:12])[CH3:11])=[N:4][CH:5]=[CH:6][CH:7]=1)(=[O:24])[CH3:23]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 24960136HCID 24960136, compound

Product 1

HCID 24960137HCID 24960137, compound

Procedure

Acetylation of N-(3-Amino-pyridin-2-yl)-2-(6-chloro-pyridin-2-yloxy)-2-methyl-propionamide using acetyl chloride gives N-(3-Acetylamino-pyridin-2-yl)-2-(6-chloro-pyridin-2-yloxy)-2-methyl propionamide 1H NMR (400 MHz, CDCl3):): δ 1.79 (s, 6H), 2.12 (s, 3H), 6.83 (d, 1H, J=8 Hz), 6.90 (d, 1H, J=8 Hz), 7.25 (t, 1H, J=8 Hz), 7.54 (t, 1H, J=8 Hz), 7.85 (brs, 1H), 8.14 (d, 1H, J=8 Hz), 8.26 (d, 1H, J=8 Hz), 9.61 (brs, 1H), MS (EI) m/z: 349 (M+1), mp: 185° C.

Sources & evidence

ORD record: ord-99149fae63c9427eb884deeda334dc26
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08940900B2

Reaction notes

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