Lithium Hydroxide → HCID 59363821, compound

Participants

Reaction Steps

To a solution of 2-Methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid ethyl ester (0.24 g, 0.608 mmol) in THF (15 ml) was added a solution of LiOH (0.127 g, 3.03 mmol) in water (3.4 ml) and stirred at r.t. for 18 h. After evaporation of the solvent, the residue was diluted with ethyl acetate (100 ml); cool to 0° C., acidified with 1N HCl (pH˜3-4). The organic phase were washed with, brine (20 ml) and dried over Na2SO4 and concentrated to get 2-Methyl-2-{3-[2-(4-trifluoromethyl-phenyl)-ethylamino]-phenoxy}-propionic acid (0.075 g, 33%). 1H NMR (400 MHz, CDCl3): δ 1.588 (s, 6H), 2.97 (t, J=6.8 Hz, 2H), 3.41 (t, J=6.8 Hz, 2H), 6.22 (s, 1H), 6.30 (d, J=8.4 Hz, 1H), 6.37 (d, J=8 Hz, 1H), 7.08 (t, J=8.0 Hz, 1H), 7.32 (d, J=8 Hz, 2H), 7.57 (d, J=7.6 Hz, 2H).

Provenance & Evidence