Methanol → Methyl 2-(4-(methylsulfonyl)phenyl)acetate

Participants

Reaction Steps

A solution of (4-Methanesulfonyl-phenyl)-acetic acid (25 g, 116.69 mmol) in methanol (300 ml) is treated with catalytic amount of sulfuric acid (2 ml). The reaction mixture was refluxed for 24 h. The solvent was then removed under reduced pressure, residue was dissolve in ethyl acetate (200 ml), the organic layer washed with water (2×100 ml), brine (100 ml), dried over sodium sulfate, and solvent was removed under reduced pressure to give (4-Methanesulfonyl-phenyl)-acetic acid methyl ester 26.37 g, 99%). 1H NMR (400 MHz, CDCl3): δ 3.06 (s, 3H), 3.73 (s, 3H), 7.50 (d, J=8.4 Hz, 2H), 7.91 (d, J=8.4 Hz, 2H).

Provenance & Evidence