N-bromobutanimide → HCID 59363842, compound

Participants

Reaction Steps

Mixture of 2-(4-Methanesulfonyl-phenyl)-propionic acid methyl ester (0.939 g, 0.3.88 mmol), N-bromosuccinimide (0.69 g, 3.88 mmol) and catalytic amount of benzoyl peroxide (0.01 g) in carbon tetrachloride (75 ml) was refluxed for 1 hour under nitrogen atmosphere, RM was cooled to room temperature and poured onto water (50 ml) under stirring, layer separated, organic layer was washed with water (2×25 ml). Removal of solvent gave the 2-Bromo-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester (1.22 g) as white solid which was used for the next step without further purification. 1H NMR (400 MHz, CDCl3): δ 2.32 (s, 3H), 3.08 (s, 3H), 3.82 (s, 3H), 7.78 (d, J=8.4 Hz, 2H), 7.94 (d, J=8.4 Hz, 2H).

Provenance & Evidence