Potassium Carbonate → HCID 59363845, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (0.15 g, 1.08 mmol) was added to a mixture of 2-Bromo-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester and 2,4-difluorophenol in DMF (5 ml) and heated at 60-70° C. for 2-3 Hrs then cool the reaction mixture to RT and poured onto water (25 ml) which was then extracted with ethyl acetate (2×25 ml), organic layer was washed with water (2×25 ml), dried over sodium sulfate and solvent was removed under reduced pressure to get 2-(2,4-Difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid methyl ester as oil which was taken in a mixture of methanol (5 ml) and sodium hydroxide in water (0.04 g in 5 ml). This mixture was stirred at room temperature for overnight. Methanol was removed from the reaction mixture, acidified with 1N HCl, extracted with ethyl acetate (2×25 ml), washed with brine (20 ml), solvent was removed to get the desired product 2-(2,4-Difluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-propionic acid. 1H NMR (400 MHz, CDCl3): δ 1.82 (s, 3H), 3.45 (s, 3H), 6.71-6.75 (m, 1H), 6.81-6.93 (m, 2H), 7.86 (d, J=8.4 Hz, 2H), 7.95 (d, J=8.4 Hz, 2H).

Provenance & Evidence