Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → Ethyl 2-(3-(((tert-butoxy)carbonyl)amino)cyclobutylidene)acetate

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-oxocyclobutylcarbamate (1.0 g, 5.4 mmol) in toluene (10 mL) was added ethyl 2-(triphenylphosphoranylidene)acetate (2.1 g, 5.9 mmol). The reaction mixture was heated at 100° C. for 2 hrs, and then concentrated. The residue was purified by silica gel column chromatography (10% EtOAc/petroleum ether) to afford ethyl 2-(3-(tert-butoxycarbonylamino)cyclobutylidene)acetate (1.2 g, 89%). ESI-MS (EI+, m/z): 256 [M+H]+.

Provenance & Evidence