Hydrochloric Acid → HCID 71533967, compound

Participants

Reaction Steps

3-(4-Adamantan-1-yl-phenoxy)-acrylic acid methylester (569 mg, 1.82 mmol) was dissolved in THF/H2O mixed solution (3:1, 20 ml), to which lithium hydroxide monohydrate (153 mg, 3.65 mmol) dissolved in purified water (5 ml) was added, followed by stirring for 12 hours. The reaction solution was treated with 10% HCl solution and extracted with ethylacetate and NaCl solution. The organic layer was dried over anhydrous MgSO4, and concentrated. The residue was purified by silica gel column chromatography (n-Hexane:EtOAc=3:1) to give the target compound as a white solid (526 mg, yield: 96.7%).

Provenance & Evidence