Hydrochloric Acid → 1-Benzhydryl-4-(3-methyloxetan-3-yl)piperazine

Participants

Reaction Steps

To a suspension of 1-benzhydryl-4-(3-((phenylsulfonyl)methyl)oxetan-3-yl)piperazine (2.49 g, 5.38 mmol) in MeOH (50 mL), THF (10 mL) was added MAGNESIUM (0.654 g, 26.9 mmol) which was pretreated with 1.0 N HCl and rinsed with MeOH, stirred at rt overnight. The Et2O was added and followed by Na2SO4.10H2O, stirred at rt for 1 hr, filtered. and filtrate was concentrated. The crude was purified by 40 g ISCO silica column, eluted with EA:HX=0-100%, the desired fractions were concentrate to yield 1-benzhydryl-4-(3-methyloxetan-3-yl)piperazine (1.08 g) as a white solid.

Provenance & Evidence