Methanesulfonyl chloride → 2-((2-Chloro-5-cyano-3-(1-(1-(methylsulfonyl)azetidin-3-yl)piperidin-4-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	HCID 86708575	HCID 86708575	—
Product	2-((2-Chloro-5-cyano-3-(1-(1-(methylsulfonyl)azetidin-3-yl)piperidin-4-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile	HCID 86708577	—

Reaction Steps

The title compound was prepared from 2-((3-(1-(azetidin-3-yl)piperidin-4-yl)-2-chloro-5-cyanophenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (Example 318) and methanesulfonyl chloride using a method analogous to that used to prepare Example 319 HPLC Rt 3.020 min

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08940736B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-591d854f2c1a4dbf8e7ab3a7b11adae1
Source note	uspto-grants-2015_01