6-Aminopicolinonitrile → HCID 86708593, compound

HRID 1430896Notes

Reaction equation

HRID 1430896 reaction equation
[CH:1]1([N:4](CC2C=CC(OC)=CC=2)[C:5]2[C:10]3=[N:11][CH:12]=[C:13]([C:14]#[N:15])[N:9]3[N:8]=[C:7](S(C)(=O)=O)[N:6]=2)[CH2:3][CH2:2]1.[NH2:29][C:30]1[N:35]=[C:34]([C:36]#[N:37])[CH:33]=[CH:32][CH:31]=1>>[C:36]([C:34]1[N:35]=[C:30]([NH:29][C:7]2[N:6]=[C:5]([NH:4][CH:1]3[CH2:2][CH2:3]3)[C:10]3=[N:11][CH:12]=[C:13]([C:14]#[N:15])[N:9]3[N:8]=2)[CH:31]=[CH:32][CH:33]=1)#[N:37]

Participants

3

Reactant 2

HCID 5642986-AminopicolinonitrileHCID 86708519HCID 86708519, compound

Product 1

HCID 86708593HCID 86708593, compound

Procedure

The compound was prepared starting from 4-(cyclopropyl(4-methoxybenzyl)amino)-2-(methylsulfonyl)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (50 mg, 0.125 mmol) and 6-aminopicolinonitrile (17.94 mg, 0.151 mmol) using the procedure for Example 1E. Material was carried forward into the next step as is.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-8cf7a8cf42df4067a9e7f790cd0b253d
Source dataset
uspto-grants-2015_01
Patent number
US08940736B2

Reaction notes

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