3-Oxetanone → HCID 86708599, compound

HRID 1430899Notes

Reaction equation

[NH:1]1[CH2:4][CH:3]([C:5]2[C:6]([Cl:38])=[C:7]([NH:13][C:14]3[N:19]=[C:18]([N:20]([CH:30]4[CH2:32][CH2:31]4)CC4C=CC(OC)=CC=4)[C:17]4=[N:33][CH:34]=[C:35]([C:36]#[N:37])[N:16]4[N:15]=3)[CH:8]=[C:9]([C:11]#[N:12])[CH:10]=2)[CH2:2]1.[O:39]1[CH2:42][C:41](=O)[CH2:40]1>>[Cl:38][C:6]1[C:5]([CH:3]2[CH2:2][N:1]([CH:41]3[CH2:42][O:39][CH2:40]3)[CH2:4]2)=[CH:10][C:9]([C:11]#[N:12])=[CH:8][C:7]=1[NH:13][C:14]1[N:19]=[C:18]([NH:20][CH:30]2[CH2:32][CH2:31]2)[C:17]2=[N:33][CH:34]=[C:35]([C:36]#[N:37])[N:16]2[N:15]=1

Participants

Reactant 2

HCID 150242543-Oxetanone

HCID 86708598HCID 86708598, compound

Product 1

HCID 86708599HCID 86708599, compound

Procedure

The title compound, was prepared from 2-((3-(azetidin-3-yl)-2-chloro-5-cyanophenyl)amino)-4-(cyclopropyl(4-methoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (Example 357E) and oxetan-3-one using a method analogous to that used to prepare Example 357.

Sources & evidence

ORD record: ord-82c71359e74a4ca1a4e2c6986c3ab9a0
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08940736B2

Reaction notes

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