HCID 23093062, compound → HCID 86659564, compound

HRID 1431023Notes

Reaction equation

[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:14][C:15]2[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=2)[CH:13]=1)[C:8]([OH:10])=O)([CH3:3])[CH3:2].[CH2:25]([O:27][P:28]([CH2:33][NH:34][C:35]([C:37]1[N:38]=[C:39]([NH2:42])[S:40][CH:41]=1)=[O:36])(=[O:32])[O:29][CH2:30][CH3:31])[CH3:26]>>[CH2:25]([O:27][P:28]([CH2:33][NH:34][C:35]([C:37]1[N:38]=[C:39]([NH:42][C:8](=[O:10])[C:7]2[CH:11]=[C:12]([O:14][C:15]3[CH:16]=[CH:17][C:18]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:19][CH:20]=3)[CH:13]=[C:5]([O:4][CH:1]([CH3:2])[CH3:3])[CH:6]=2)[S:40][CH:41]=1)=[O:36])(=[O:32])[O:29][CH2:30][CH3:31])[CH3:26]

Participants

Reactant 2

HCID 23093062HCID 23093062, compound

HCID 58529065HCID 58529065, compound

Product 1

HCID 86659564HCID 86659564, compound

Procedure

The above prepared 3-isopropoxy-5-(4-methanesulfonyl-phenoxy)-benzoic acid is coupled with {[(2-amino-thiazole-4-carbonyl)-amino]-methyl}-phosphonic acid diethyl ester following the procedure described in Example 1, Step D to give [({2-[3-isopropoxy-5-(4-methanesulfonyl-phenoxy)-benzoylamino]-thiazole-4-carbonyl}-amino)-methyl]-phosphonic acid diethyl ester.

Sources & evidence

ORD record: ord-aae76a376287480a9753a7487d5efe6d
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08940927B2

Reaction notes

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