HCID 66742512, compound → HCID 66742896, compound

HRID 1431057Notes

Reaction equation

HRID 1431057 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[C:18]([CH2:53][OH:54])=[C:19]([C:23]3[CH:24]=[C:25]([NH:31][C:32]4[N:37]=[CH:36][C:35]([N:38]5[CH:43]6[CH2:44][CH2:45][CH:39]5[CH2:40][N:41](C(OC(C)(C)C)=O)[CH2:42]6)=[CH:34][CH:33]=4)[C:26](=[O:30])[N:27]([CH3:29])[N:28]=3)[CH:20]=[CH:21][CH:22]=1)[N:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2]>ClCCl>[CH:39]12[N:38]([C:35]3[CH:34]=[CH:33][C:32]([NH:31][C:25]4[C:26](=[O:30])[N:27]([CH3:29])[N:28]=[C:23]([C:19]5[C:18]([CH2:53][OH:54])=[C:17]([N:10]6[N:9]=[CH:8][C:7]7[C:12](=[C:13]([F:15])[CH:14]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=7)[C:11]6=[O:16])[CH:22]=[CH:21][CH:20]=5)[CH:24]=4)=[N:37][CH:36]=3)[CH:43]([CH2:44][CH2:45]1)[CH2:42][NH:41][CH2:40]2

Participants

3

Reactant 1

HCID 66742512HCID 66742512, compound

Product 1

HCID 66742896HCID 66742896, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl 8-(6-(6-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-2-methyl-3-oxo-2,3-dihydropyridazin-4-ylamino)pyridin-3-yl)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate (90 mg, 122 umol) was de-BOC with 50% trifluoro acid in dichloromethane (10 mL) for 2 hr. The reaction mixture was concentrated to dryness, then partitioned between ethyl acetate and saturated sodium bicarbonate. The organic phase was dried over sodium sulfate, filtered and concentrated.

Workup

  1. customfor 2 hr
  2. concentrationThe reaction mixture was concentrated to dryness
  3. custompartitioned between ethyl acetate and saturated sodium bicarbonate
  4. dry with materialThe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-30b018c13b964eb895ba227ca378c5b4
Source dataset
uspto-grants-2015_01
Patent number
US08940741B2

Reaction notes

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